Oral Bioavailability of Nonpolar Organic Chemicals in Soil for Use in Human Health Risk Assessment

This report provides a review of bioavailability studies and methods in relation to human health risk assessment for PAHs and PCBs.

Moreover standard in vitro methods to evaluate oral PAH and PCB bioavailability in soil are assessed with the aim of giving support to adjustments to risk-based soil cleanup levels for contaminated land. Furthermore various differences among countries (i.e., the US, UK, The Netherlands, France, Canada, and Australia) in the regulatory approaches to evaluating and using bioavailability in risk assessment are summarized, including definitions of terms, test methods that are deemed acceptable, reporting requirements, regulatory frameworks, and guidance on specific chemicals.