Environmental Project No. 1503, 2013

Use of QSAR to identify potential CMR substances of relevance under the REACH regulation


Substances classified as carcinogenic, mutagenic or toxic for reproduction (CMR) (>1 Ton) should have been registered under RECAH by December 2010. However, it is well-known that for low tonnage EU industrial substances the majority have few or no experimental CMR test data. QSAR models were applied to screen around 68,000 REACH pre-registered substances for CMR properties. The Nordic substance register database (SPIN) was used to identify not registered substances where human exposure is likely to be significant. The results can serve as an observation list for Industry and can be used by authorities for future priority setting for e.g. targeted experimental confirmatory testing and for the REACH registered substances for potential inclusion on the EU CORAP list.

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