Organophosphate metabolites in urine samples from Danish children and women

Organophosphate metabolites in urine samples from Danish children and women

01-09-2016

This report describes the concentrations of six dialkylphosphate metabolites (DAPs) used as biomarkers for organophosphate exposure in Danish school children and mothers participating in the European project DEMOCOPHES.
The findings of relatively high detection frequency of DAP indicate that there is still a widespread exposure to organophosphate pesticides in the Danish population, even though there have been major restrictions on their use in agriculture. Chlorpyrifos is likely to be an important contributor to the DAP found since it is often found in samples of imported fruit and vegetables, which is considered the main exposure source for OPs in Denmark.
The concentrations of the DAPs found in the children and women of the present study are in line with what was found in Europe and previous measurements in Denmark. However, methylated metabolites seem to have decreased in Denmark compared to previous measurements in 2007-08 and levels found in other European countries before 2007.
Exposure to OPs has been associated with adverse health effects in some studies in USA, hence, there may also be a risk of adverse effects in Europe and Denmark, as we have found even higher levels of exposure.

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